Dihexa (PNB-0408), an oligopeptide reagent, is an angiotensin IV analog with oral activity and permeability of the blood-brain barrier. Dihexa binds to Hepatocyte Chemicalbook Growth Facto with high affinity, with a Kd value of 65pM, and enhances its activity on the receptor c-Met. Dihexa has shown excellent antipsychotic activity and improved cognitive function in animal models.
Product name |
Dihexa |
Manufacture date |
Jan.15.2025 |
Batch number |
SW250115 |
Analysis date |
Jan.16.2025 |
Batch quantity |
10kg |
Expiry date |
Jan.15.2027 |
Items |
Specifications |
Results |
Appearance |
White powder |
Complies |
Purity |
99%min |
99.29% |
Single Impurity (HPLC) |
1.0%max |
0.61% |
Amino Acid Composition |
±10% of theoretical |
Complies |
Peptide Content (N%) |
≥80.0% |
81.79% |
Water Content(Karl Fischer) |
≤6.0% |
3.09% |
Acetate Content (HPIC) |
≤15.0% |
10.84% |
MS(ESI) |
Consistent |
Complies |
Mass Balance |
95.0~105.0% |
Complies |
Specific Rotation (20/D) |
-65.0~-75.0°(c=0.5 1%HAc) |
Complies |
Solubility |
H 2 O:40 mg / mL |
Complies |
Conclusion |
Conform to specifications |
Packing description: |
Sealed export grade drum & double of sealed plastic bag |
Storage: |
Store in cool & dry place not freeze, keep away from strong light and heat |
Shelf life: |
2 years when properly stored |
Dihexa dramatically improves cognitive function in animal models of Alzheimer's disease-like mental impairment. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor.









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